Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients

Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients

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Background: Organ transplant recipients (OTRs) have a Switch Blade Opener very high risk of developing cutaneous squamous cell carcinoma (cSCC).Immunosuppressed OTRs may have a higher proportion of poorly differentiated cSCC than non-OTRs.Objectives: The aim of this study was to investigate the degree of differentiation of cSCCs in OTRs compared with immunocompetent individuals.

Patients/Methods: Data from the Swedish Cancer Registry were crosschecked with data from the Transplant registry of the Transplant Institute at Sahlgrenska University Hospital in Gothenburg, Sweden.All OTRs with a diagnosis of cSCC, basosquamous carcinoma, and/or cSCC in situ established at the Department of Dermatology, Sahlgrenska University Hospital, during 2002-2015 were included.The control group consisted of non-OTRs with the same diagnoses during the same time period.

Results: During 2002-2015, 82 OTRs diagnosed with 515 tumors and 883 non-OTRs with 1,247 tumors were included.OTRs developed 0.47 tumors/year vs 0.

10 tumors/year for non-OTRs, but no significant differences were observed in the degree of tumor differentiation of invasive cSCCs between OTRs and non-OTRs (P = 0.4).The distribution of poorly, moderately, and well-differentiated invasive cSCCs among OTRs and non-OTRs were 8.

5% vs 5 Piece Bunk Bed Bedroom 12.5%, 22.1% vs 29.

9%, and 69.4% vs 57.6%, respectively.

Conclusions: OTRs do not develop a higher proportion of poorly differentiated cSCCs than non-OTRs.